Publication highlights

2020

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

PNAS

Jennifer Yeung, Reheman Adili, Emily N. Stringham, Rong Luo, Alexander Vizurraga, Luciana K. Rosselli-Murai, Hannah M. Stoveken, Maiya Yu, Xianhua Piao, Michael Holinstat, and Gregory G. Tall

DOI: 10.1073/pnas.2008921117

A plug-and-latch mechanism for gating the mechanosensitive piezo channel

Neuron

Jie Geng, Wenhao Liu, Heng Zhou, Tingxin Zhang, Li Wang, Mingmin Zhang, Yiran Li, Bo Shen, Xueming Li, Bailong Xiao

DOI: 10.1016/j.neuron.2020.02.010

Timing the extant avian radiation: The rise of modern birds, and the importance of modeling molecular rate variation. Pennaraptoran Theropod Dinosaurs : Past Progress and New Frontiers.

Bulletin of the American Museum of Natural History, No. 440

Daniel J. Field, Jacob S. Berv, Allison Y. Hsiang, Robert Lanfear, Michael J. Landis, Alex Dornburg

Engineered immunological niches to monitor disease activity and treatment efficacyin relapsing multiple sclerosis

Nature Communications

Aaron H. Morris, Kevin R. Hughes, Robert S. Oakes, Michelle M. Cai, Stephen D. Miller,David N. Irani & Lonnie D. Shea

DOI: 10.1038/s41467-020-17629-z

The heating microenvironment: Intercellular cross talk within thermogenic adipose tissue

Diabetes

Alexander J. Knights, Jun Wu, Yu-Hua Tseng

DOI: 10.2337/db20-0303

Adrenergic-independent signaling via CHRNA2 regulates beige fat activation

Developmental Cell

Heejin Jun, Yingxu Ma, Yong Chen, Jianke Gong, Shanshan Liu, Jine Wang, Alexander J. Knights, Xiaona Qiao, Margo P. Emont, X.Z. Shawn Xu, Shingo Kajimura, Jun Wu

DOI: 10.1016/j.devcel.2020.05.017

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

Nature Communications

Alexander J. Knights, Emily J. Vohralik, Peter J. Houweling, Elizabeth S. Stout, Laura J. Norton, Stephanie J. Alexopoulos, Jinfen. J. Yik, Hanapi Mat Jusoh, Ellen M. Olzomer, Kim S. Bell-Anderson, Kathryn N. North, Kyle L. Hoehn, Merlin Crossley & Kate G. R. Quinlan

DOI: 10.1038/s41467-020-16758-9

Frontiers in Neuroscience

Pilar Rivero-Ríos, María Romo-Lozano, Rachel Fasiczka, Yahaira Naaldijk, Sabine Hilfiker

DOI: 10.3389/fnins.2020.00556

High-throughput cryo-EM enabled by user-free preprocessing routines

Structure

Yilai Li, Jennifer N. Cash, John J.G. Tesmer, Michael A. Cianfrocco

DOI: 10.1016/j.str.2020.03.008

Bacterial lyso-form lipoproteins are synthesized via an intramolecular acyl chain migration

Journal of Biological Chemistry

Krista M. Armbruster, Gloria Komazin, Timothy C. Meredith

DOI: 10.1074/jbc.RA120.014000

Engineered niches to analyze mechanisms of metastasis and guide precision medicine

Cancer Research

Aaron H. Morris, Sophia M. Orbach, Grace G. Bushnell, Robert S. Oakes, Jacqueline S. Jeruss, Lonnie D. Shea

DOI: 10.1158/0008-5472.CAN-20-0079

Krüppel-like factor 3 (KLF3) suppresses NF-kB–driven inflammation in mice

Journal of Biological Chemistry

Alexander J. Knights, Lu Yang, Manan Shah, Laura J. Norton, Gamran S. Green, Elizabeth S. Stout, Emily J. Vohralik, Merlin Crossley, Kate G.R. Quinlan

DOI: 10.1074/jbc.RA120.013114

EoTHINophils: Eosinophils as key players in adipose tissue homeostasis

Clinical and Experimental Pharmacology and Physiology

Emily J. Vohralik, Annalise M. Psaila, Alexander J. Knights, Kate G.R. Quinlan

DOI: 10.1111/1440-1681.13304

Null models for community dynamics: Beware of the cyclic shift algorithm

Global Ecology and Biogeography

Michael Kalyuzhny

DOI: 10.1111/geb.13083

Metastatic conditioning of myeloid cells at a subcutaneous synthetic niche reflects disease progression and predicts therapeutic outcomes

Cancer Research

Robert S. Oakes, Grace G. Bushnell, Sophia M. Orbach, Pridvi Kandagatla, Yining Zhang, Aaron H. Morris, Matthew S. Hall, Petrina LaFaire, Joseph T. Decker, Rachel M. Hartfield, Michael D. Brooks, Max S. Wicha, Jacqueline S. Jeruss, Lonnie D. Shea

DOI: 10.1158/0008-5472.CAN-19-1932

Origin and evolution of carboxysome positioning systems in cyanobacteria

Molecular Biology and Evolution

Joshua S. MacCready, Joseph L. Basalla, Anthony G. Vecchiarelli

DOI: 10.1093/molbev/msz308

Physical limits to sensing material properties

Nature Communications

Farzan Beroz, Di Zhou, Xiaoming Mao, David K. Lubensky

DOI: 10.1038/s41467-020-18995-4

2019

Cell-line specific RNA editing patterns in Trypanosoma brucei suggest a unique mechanism to generate protein variation in a system intolerant to genetic mutations

Nucleic Acids Research

Laura E. Kirby, Donna Koslowsky

DOI: 10.1093/nar/gkz1131

R-BIND: An interactive database for exploring and developing RNA-targeted chemical probes

ACS Chemical Biology

Brittany S. Morgan, Bilva G. Sanaba, Anita Donlic, Diane B. Karloff, Jordan E. Forte, Yuqi Zhang, Amanda E. Hargrove

DOI: 10.1021/acschembio.9b00631

Protein arginine methyltransferase 1 interacts with PGC1α and modulates thermogenic fat activation

Endocrinology

Xiaona Qiao, Dong-il Kim, Heejin Jun, Yingxu Ma, Alexander J. Knights, Min-Jung Park, Kezhou Zhu, Jay H. Lipinski, Jiling Liao, Yiming Li, Stéphane Richard, Steven A. Weinman, Jun Wu

DOI: 10.1210/en.2019-00504

Fitness effects but no temperature-mediated balancing selection at the polymorphic Adh gene of Drosophila melanogaster

PNAS

Mohammad A. Siddiq and Joseph W. Thornton

DOI: 10.1073/pnas.1909216116

Elevated thrombospondin-2 contributes to delayed wound healing in diabetes

Diabetes

Britta Kunkemoeller, Tara Bancroft, Hao Xing, Aaron H. Morris, Amelia K. Luciano, Jason Wu, Carlos Fernandez-Hernando, Themis R. Kyriakides

DOI: 10.2337/db18-1001

Characterization of glucose transporter 6 in lipopolysaccharide-induced bone marrow-derived macrophage function

The Journal of Immunology

Beth T. Caruana, Frances L. Byrne, Alexander J. Knights, Kate G. R. Quinlan, Kyle L. Hoehn

DOI: 10.4049/jimmunol.1801063

2018

Protein gradients on the nucleoid position the carbon-fixing organelles of cyanobacteria

eLife

Joshua S. MacCready, Pusparanee Hakim, Eric J. Young, Longhua Hu, Jian Liu, Katherine W. Osteryoung, Anthony G. Vecchiarelli, Daniel C. Ducat

DOI: 10.7554/eLife.39723

Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules

Crisbel M. Artuz, Alexander J. Knights, Alister P.W. Funnell, Thomas J. Gonda, Katya Ravid, Richard C.M. Pearson, Kate G.R. Quinlan, Merlin Crossley

DOI: 10.1016/j.btre.2018.e00285

Tunable hydrogels derived from genetically engineered extracellular matrix accelerate diabetic wound healing

ACS Applied Materials & Interfaces

Aaron H. Morris, Hudson Lee, Hao Xing, Danielle K. Stamer, Marina Tan, Themis R. Kyriakides

DOI: 10.1021/acsami.8b08920

LMO7 Is a negative feedback regulator of transforming growth factor β signaling and fibrosis

Circulation

Yi Xie, Allison C. Ostriker, Yu Jin, Haidi Hu, Ashley J. Sizer, Gang Peng, Aaron H. Morris, Changwan Ryu, Erica L. Herzog, Themis Kyriakides, Hongyu Zhao, Alan Dardik, Jun Yu, John Hwa, Kathleen A. Martin

DOI: 10.1161/CIRCULATIONAHA.118.034615

Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds

Biomaterials

Aaron H. Morris, Danielle K. Stamer, Britta Kunkemoeller, Julie Chang, HaoXing, Themis R. Kyriakides

DOI: 10.1016/j.biomaterials.2018.03.049

Nanopatterned bulk metallic glass-based biomaterials modulate macrophage polarization

Acta Biomaterialia

Mahdis Shayan, Jagannath Padmanabhan, Aaron H. Morris, Bettina Cheung, Ryan Smith. Jan Schroers, Themis R. Kyriakides

DOI: 10.1016/j.actbio.2018.05.051

Verticalization of bacterial biofilms

Nature Physics

Farzan Beroz, Jing Yan, Yigal Meir, Benedikt Sabass, Howard A. Stone, Bonnie L. Bassler, Ned S. Wingreen

DOI: 10.1038/s41567-018-0170-4